Article
Targeting NRAS in melanoma.
Cancer journal (Sudbury, Mass.) - 1 Jan 2000
Kelleher Fergal C, McArthur Grant A
Abstract excerpt
Cutaneous melanomas have mutations in the NRAS GTPase in 15% of cases. Compared to melanomas with BRAF mutations, or melanomas "wild-type" for BRAF and NRAS, melanomas with NRAS mutations are more likely to be thicker tumors and to have a higher mitotic rate. Preclinical studies indicate that melanoma cells with NRAS mutations are dependent on NRAS for survival and proliferation, making NRAS an attractive...
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