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Article

Neuregulin-1 (NRG1) polymorphisms linked with psychosis transition are associated with enlarged lateral ventricles and white matter disruption in schizophrenia.

Psychological medicine - 1 Apr 2018

Bousman C A, Cropley V, Klauser P, Hess J L, Pereira A, Idrizi R, Bruggemann J, Mostaid M S, Lenroot R, Weickert T W, Glatt S J, Everall I P, Sundram S, Zalesky A, Weickert C S, Pantelis C

Abstract excerpt

BACKGROUND: Two single-nucleotide polymorphisms (SNPs) (rs4281084 and rs12155594) within the neuregulin-1 (NRG1) gene have been associated with psychosis transition. However, the neurobiological changes associated with these SNPs remain unclear. We aimed to determine what relationship these two SNPs have on lateral ventricular volume and white matter integrity, as abnormalities in these brain structures are some...

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Identifiers

PMID: 28826413
DOI: 10.1017/S0033291717002173

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NRG1

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