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Neuregulin-1 genotype is associated with structural differences in the normal human brain.

NeuroImage - 1 Feb 2012

Barnes Anna, Isohanni Matti, Barnett Jennifer H, Pietiläinen Olli, Veijola Juha, Miettunen Jouko, Paunio Tiina, Tanskanen Päivikki, Ridler Khanum, Suckling John, Bullmore Edward T, Jones Peter B, Murray Graham K

Abstract excerpt

The human neuregulin-1 (NRG-1) gene is highly expressed in the brain, is implicated in numerous functions associated with neuronal development, and is a leading candidate gene for schizophrenia. The T allele of SNP8NRG243177, part of a risk haplotype for schizophrenia, has been previously associated with decreases in white matter in the right anterior internal capsule and the left anterior thalamic radiation. To...

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Brain Mapping
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PMID: 22019858
DOI: 10.1016/j.neuroimage.2011.10.007

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