Article
A Neuregulin-1 schizophrenia susceptibility variant causes perihippocampal fiber tract anomalies in healthy young subjects.
Brain and behavior - 1 Mar 2014
Nickl-Jockschat Thomas, Stöcker Tony, Krug Axel, Markov Valentin, Huang Ruiwang, Schneider Frank, Habel Ute, Eickhoff Simon B, Zerres Klaus, Nöthen Markus M, Treutlein Jens, Rietschel Marcella, Shah Nadim Jon, Kircher Tilo
Abstract excerpt
BACKGROUND: Changes in fiber tract architecture have gained attention as a potentially important aspect of schizophrenia neuropathology. Although the exact pathogenesis of these abnormalities yet remains to be elucidated, a genetic component is highly likely. Neuregulin-1 (NRG1) is one of the best-validated schizophrenia susceptibility genes. We here report the impact of the Neuregulin-1 rs35753505 variant on...
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