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Article

GADD45A plays a protective role against temozolomide treatment in glioblastoma cells

14 Aug 2017

Abstract excerpt

Abstract Glioblastoma multiforme (GBM) is one of the most aggressive cancers. Despite recent advances in multimodal therapies, high-grade glioma remains fatal. Temozolomide (TMZ) is an alkylating agent used worldwide for the clinical treatment of GBM; however, the innate and acquired resistance of GBM limits its application. Here, we found that TMZ inhibited the proliferation and induced the G2/M arrest of GBM...

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PMID: 28821714
DOI: 10.1038/s41598-017-06851-3

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