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Article

ABT-888 restores sensitivity in temozolomide resistant glioma cells and xenografts

28 Aug 2018

Abstract excerpt

BACKGROUND: Temozolomide (TMZ) is active against glioblastomas (GBM) in which the O6-methylguanine-DNA methyltransferase (MGMT) gene is silenced. However, even in responsive cases, its beneficial effect is undermined by the emergence of drug resistance. Here, we tested whether inhibition of poly (ADP-ribose) polymerase-1 and -2 (PARP) enhanced the effectiveness of TMZ. METHODS: Using patient derived brain tumor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30153289
DOI: 10.1371/journal.pone.0202860

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