Article

Downregulated the expression of DNMT3B by suppressing PI3K/Akt signaling pathway and enhances the chemosensitivity of glioblastoma to temozolomide.

2023-10-03

Abstract excerpt

<title>Abstract</title> <p>Purpose Glioblastoma is the most common malignant brain tumors and has the poorest prognosis. And a poor prognosis is attributed to chemoresistance to temozolomide (TMZ), the first-line drug for treating glioblastoma. This study aimed to investigate how to enhance the chemosensitivity of glioblastoma to temozolomide. Methods Human glioblastoma cell line U251 was used to established te...

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Literature Corpus work: beb9e15a-b2e6-519f-86e3-659af8c307b4
DOI: 10.21203/rs.3.rs-3358904/v1

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