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Article

Gene Signatures of 1,25‐Dihydroxyvitamin D<sub>3</sub> Exposure in Normal and Transformed Mammary Cells

3 Mar 2015

Abstract excerpt

To elucidate potential mediators of vitamin D receptor (VDR) action in breast cancer, we profiled the genomic effects of its ligand 1,25-dihydroxyvitamin D3 (1,25D) in cells derived from normal mammary tissue and breast cancer. In non-transformed hTERT-HME cells, 483 1,25D responsive entities in 42 pathways were identified, whereas in MCF7 breast cancer cells, 249 1,25D responsive entities in 31 pathways were...

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PMID: 25736056
DOI: 10.1002/jcb.25129

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