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Article

Selective estrogen receptor modulators and pharmacogenomic variation in ZNF423 regulation of BRCA1 expression: individualized breast cancer prevention.

Cancer discovery - 1 Jul 2013

Ingle James N, Liu Mohan, Wickerham D Lawrence, Schaid Daniel J, Wang Liewei, Mushiroda Taisei, Kubo Michiaki, Costantino Joseph P, Vogel Victor G, Paik Soonmyung, Goetz Matthew P, Ames Matthew M, Jenkins Gregory D, Batzler Anthony, Carlson Erin E, Flockhart David A, Wolmark Norman, Nakamura Yusuke, Weinshilboum Richard M

Abstract excerpt

The selective estrogen receptor modulators (SERM) tamoxifen and raloxifene can reduce the occurrence of breast cancer in high-risk women by 50%, but this U.S. Food and Drug Administration-approved prevention therapy is not often used. We attempted to identify genetic factors that contribute to va...

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Source

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Identifiers

PMID: 23764426
DOI: 10.1158/2159-8290.CD-13-0038
PMCID: PMC3710533

Genes

BRCA1
CTSO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23764426-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Selective estrogen receptor modulators and pharmacogenomic variation in ZNF423 regulation of BRCA1 expression: individualized breast cancer prevention.PMID 23764426Read ↗

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