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Article

AKT-dependent phosphorylation of the SAM domain induces oligomerization and activation of the scaffold protein CNK1.

Biochimica et biophysica acta. Molecular cell research - 1 Jan 2017

Fischer Adrian, Weber Wilfried, Warscheid Bettina, Radziwill Gerald

Abstract excerpt

Scaffold proteins are hubs for the coordination of intracellular signaling networks. The scaffold protein CNK1 promotes several signal transduction pathway. Here we demonstrate that sterile motif alpha (SAM) domain-dependent oligomerization of CNK1 stimulates CNK1-mediated signaling in growth factor-stimulated cells. We identified Ser22 located within the SAM domain as AKT-dependent phosphorylation site...

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Identifiers

PMID: 27769899
DOI: 10.1016/j.bbamcr.2016.10.009

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EGF

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