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Article

Induction of Cyclooxygenase 2 by Streptococcus pyogenes Is Mediated by Cytolysins.

Journal of innate immunity - 1 Jan 2017

Blaschke Ulrike, Beineke Andreas, Klemens Johanna, Medina Eva, Goldmann Oliver

Abstract excerpt

Prostaglandin E2 (PGE2), an arachidonic acid metabolite regulating a broad range of physiological activities, is an important modulator of the severity of infection caused by Streptococcus pyogenes. Here, we investigated the role of streptococcal cytolysin S (SLS) and streptococcal cytolysin O (SLO) in the induction of cyclooxygenase-2 (COX-2), the rate-limiting enzyme in the synthesis of prostaglandins, in in...

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Identifiers

PMID: 28813715
DOI: 10.1159/000479153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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