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Article

TP53 Mutational Status and ROS Effect the Expression of the Survivin-Associated Radio-Adaptive Response.

Radiation research - 1 Nov 2017

Murley Jeffrey S, Miller Richard C, Weichselbaum Ralph R, Grdina David J

Abstract excerpt

A survivin-associated radio-adaptive response, characterized by increased radiation resistance or sensitization, was induced by exposure to 5 mGy of ionizing radiation and was correlated to the TP53 mutational status of exposed cells. Ten human cancer lines were investigated: colorectal carcinomas HCT116 and RKO [TP53 wild-type (WT)] and their respective TP53 null isogenic lines; breast adenocarcinomas MCF7 (TP53...

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Identifiers

PMID: 28813624
DOI: 10.1667/RR14831.1
PMCID: PMC5705057

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