X Radiation Causes a Persistent Induction of Reactive Oxygen Species and a Delayed Reinduction of TP53 in Normal Human Diploid Fibroblasts

doi:10.1667/0033-7587(2002)158[0210:xrcapi]2.0.co;2

Article

X Radiation Causes a Persistent Induction of Reactive Oxygen Species and a Delayed Reinduction of TP53 in Normal Human Diploid Fibroblasts

1 Aug 2002

Abstract excerpt

Multiple genetic changes are required for the development of a malignant cell. The frequency of such changes in cancer cells is higher than can be explained through random mutation, and it was proposed that a subpopulation of cells develop a persistent mutator phenotype. Evidence for such a phenotype has been observed in mammalian cells after treatment with ionizing radiation. The mechanism that promotes this...

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