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RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio.

BMC genomics - 7 Feb 2020

Saddala Madhu Sudhana, Lennikov Anton, Bouras Adam, Huang Hu

Abstract excerpt

BACKGROUND: Retinal degenerative diseases affect millions of people and represent the leading cause of vision loss around the world. Retinal degeneration has been attributed to a wide variety of causes, such as disruption of genes involved in phototransduction, biosynthesis, folding of the rhodopsin molecule, and the structural support of the retina. The molecular pathogenesis of the biological events in retinal...

Topics

Animals
Cyclic Nucleotide Phosphodiesterases, Type 6
Gene Ontology
Gene Regulatory Networks
Light Signal Transduction
Mutation
RNA-Seq
Retina
Retinal Degeneration
Zebrafish
Zebrafish Proteins

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PMID: 32033529
DOI: 10.1186/s12864-020-6550-z
PMCID: PMC7006399

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