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Article

Molecular genetic evidence for heterogeneity in manic depression.

Nature - 1 Jan 2000

Hodgkinson S, Sherrington R, Gurling H, Marchbanks R, Reeders S, Mallet J, McInnis M, Petursson H, Brynjolfsson J

Abstract excerpt

Manic depression is a severe cyclic mental illness that can be unipolar or bipolar and has a lifetime risk of approximately 7 per 1,000 in most populations. Families with multiple cases of manic depression have been described that are compatible with both autosomal dominant and X-linked modes of genetic transmission. Psychoactive antidepressant and stimulant drugs that help to ameliorate depression and mania are...

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Source

Identifiers

PMID: 2881210
DOI: 10.1038/325805a0

Genes

INS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Molecular genetic evidence for heterogeneity in manic depression.PMID 2881210Read ↗

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Linkage of c-Harvey-ras-1 and INS DNA markers to unipolar depression and alcoholism is ruled out in 18 families.Semantic proximity Read ↗

Linkage analysis of manic depression (bipolar affective disorder) in Icelandic and British kindreds using markers on the short arm of chromosome 18.Semantic proximity Read ↗

Tyrosine hydroxylase gene not linked to manic-depression in seven of eight pedigrees.Semantic proximity Read ↗

Genetic associations with clinical characteristics in bipolar affective disorder and recurrent unipolar depressive disorderSemantic proximity Read ↗

Two-locus admixture linkage analysis of bipolar and unipolar affective disorder supports the presence of susceptibility loci on chromosomes 11p15 and 21q22.Semantic proximity Read ↗

Manic depressive illness and tyrosine hydroxylase gene: linkage heterogeneity and association.Semantic proximity Read ↗

Linkage analysis of the D1 dopamine receptor gene and manic depression in six families.Semantic proximity Read ↗

Exclusion of linkage between manic depressive illness and tyrosine hydroxylase and dopamine D2 receptor genes.Semantic proximity Read ↗

Linkage analysis between manic-depressive illness and 35 classical markers.Semantic proximity Read ↗

Evidence against close linkage of unipolar affective illness to human chromosome 11p markers HRAS1 and INS and chromosome Xq marker DXS52.Semantic proximity Read ↗

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