Linkage of c-Harvey-ras-1 and INS DNA markers to unipolar depression and alcoholism is ruled out in 18 families.

doi:10.1007/BF01734541

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Article

Linkage of c-Harvey-ras-1 and INS DNA markers to unipolar depression and alcoholism is ruled out in 18 families.

European archives of psychiatry and neurological sciences - 1 Jan 1990

Wesner R B, Tanna V L, Palmer P J, Goedken R J, Crowe R R, Winokur G

Abstract excerpt

Eighteen families informative for c-Harvey-ras-1 and INS DNA markers were tested for linkage to unipolar depression and alcoholism. No evidence of linkage was found between these DNA markers and the disorders observed in the families. This study fails to replicate the Old Order Amish Study and suggests that a significant degree of genetic heterogeneity may be present among psychiatric disorders.

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Alcoholism
Chromosomes, Human, Pair 11
DNA
DNA Probes
Depressive Disorder
Female
Genetic Linkage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Markers

Genotype

Humans

Male

Middle Aged

Pedigree

Phenotype

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Open in PubMed

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PMID: 2144234
DOI: 10.1007/BF01734541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2144234-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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