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Article

Multimerization is required for antigen binding activity of an engineered IgM/IgG chimeric antibody recognizing a skin-related antigen.

Scientific reports - 15 Aug 2017

Teye Kwesi, Hashimoto Koji, Numata Sanae, Ohta Kunihiro, Haftek Marek, Hashimoto Takashi

Abstract excerpt

Monoclonal antibodies offer great tools for research. We encountered a potentially useful mouse IgM monoclonal antibody whose antigen is expressed in normal skin but lost in human skin cancer. Because IgM is difficult to work with and the antigen was unknown, we decided to convert the IgM (µ) to IgG (γ) version. After cDNA for the antibody was obtained by RACE PCR, we made a series of molecules with different...

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Identifiers

PMID: 28811604
DOI: 10.1038/s41598-017-08294-2
PMCID: PMC5557880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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