Article
B-Cell-Specific Myd88 L252P Expression Causes a Premalignant Gammopathy Resembling IgM MGUS.
Frontiers in immunology - 1 Jan 2020
Schmidt Kristin, Sack Ulrike, Graf Robin, Winkler Wiebke, Popp Oliver, Mertins Philipp, Sommermann Thomas, Kocks Christine, Rajewsky Klaus
Abstract excerpt
A highly recurrent somatic L265P mutation in the TIR domain of the signaling adapter MYD88 constitutively activates NF-κB. It occurs in nearly all human patients with Waldenström's macroglobulinemia (WM), a B cell malignancy caused by IgM-expressing cells. Here, we introduced an inducible leucine to proline point mutation into the mouse Myd88 locus, at the orthologous position L252P. When the mutation was...
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