BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method.

doi:10.1101/gad.294413.116

Article

BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method.

Genes & development - 15 Mar 2017

Lim Chae-Seok, Kang Xi, Mirabella Vincent, Zhang Huaye, Bu Qian, Araki Yoichi, Hoang Elizabeth T, Wang Shiqiang, Shen Ying, Choi Sukwoo, Kaang Bong-Kiun, Chang Qiang, Pang Zhiping P, Huganir Richard L, Zhu J Julius

Abstract excerpt

Rapid advances in genetics are linking mutations on genes to diseases at an exponential rate, yet characterizing the gene-mutation-cell-behavior relationships essential for precision medicine remains a daunting task. More than 350 mutations on small GTPase BRaf are associated with various tumors, and ∼40 mutations are associated with the neurodevelopmental disorder cardio-facio-cutaneous syndrome (CFC). We...

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BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method.

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