Article
Multi-purpose utility of circulating plasma DNA testing in patients with advanced cancers.
PloS one - 1 Jan 2012
Perkins Geraldine, Yap Timothy A, Pope Lorna, Cassidy Amy M, Dukes Juliet P, Riisnaes Ruth, Massard Christophe, Cassier Philippe A, Miranda Susana, Clark Jeremy, Denholm Katie A, Thway Khin, Gonzalez De Castro David, Attard Gerhardt, Molife L Rhoda, Kaye Stan B, Banerji Udai, de Bono Johann S
Abstract excerpt
Tumor genomic instability and selective treatment pressures result in clonal disease evolution; molecular stratification for molecularly targeted drug administration requires repeated access to tumor DNA. We hypothesized that circulating plasma DNA (cpDNA) in advanced cancer patients is largely derived from tumor, has prognostic utility, and can be utilized for multiplex tumor mutation sequencing when repeat...
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