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Article

Scanning malleable transition state ensembles: comparing theory and experiment for folding protein U1A.

Biochemistry - 3 May 2005

Shen Tongye, Hofmann Christoph P, Oliveberg Mikael, Wolynes Peter G

Abstract excerpt

Using a variational free energy functional, we calculate the characteristics of the transition state ensembles (TSE) for the folding of protein U1A and investigate how they respond to thermal and mutational changes. The functional directly yields predicted chevron plots both for the wild-type protein and for various mutants. The detailed variations of the TSE and changes in chevron plots predicted by the theory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15850377
DOI: 10.1021/bi0500170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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