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Article

Integrative structural modeling of a multidomain polo-like kinase.

Physical chemistry chemical physics : PCCP - 16 Dec 2020

Ruan Hao, Kiselar Janna, Zhang Weilin, Li Siyang, Xiong Ruoyao, Liu Ying, Yang Sichun, Lai Luhua

Abstract excerpt

Polo-like kinase 1 (PLK1) is a key regulator and coordinator for mitotic signaling that contains two major functional units of a kinase domain (KD) and a polo-box domain (PBD). While individual domain structures of the KD and the PBD are known, how they interact and assemble into a functional complex remains an open question. The structural model from the KD-PBD-Map205PBM heterotrimeric crystal structure of...

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PMID: 33236741
DOI: 10.1039/d0cp05030j

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