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Article

PGC-1α in aging and lifelong exercise training-mediated regulation of UPR in mouse liver.

Experimental gerontology - 1 Nov 2017

Kristensen Caroline M, Brandt Christina T, Ringholm Stine, Pilegaard Henriette

Abstract excerpt

Aging is associated with changes in several metabolic pathways affecting liver function including the adaptive unfolded protein response (UPR). On the other hand, exercise training has been shown to exert beneficial effects on metabolism in the liver and exercise training has been reported to affect hepatic UPR. PGC-1α is a transcriptional coactivator involved in exercise training-induced adaptations in skeletal...

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Source

Identifiers

PMID: 28801170
DOI: 10.1016/j.exger.2017.08.006

Genes

PGC
ATF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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