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Article

The Influence of Aging on the Unfolded Protein Response in Human Skeletal Muscle at Rest and after Acute Exercise

27 Jun 2024

Abstract excerpt

BACKGROUND: The unfolded protein response (UPR) is a proteostatic process that is activated in response to endoplasmic reticulum stress. It is currently unclear how aging influences the chronic and adaptive UPR in human skeletal muscle. Here we determined the effect of aging on UPR activation at rest, in response to exercise, and the associations with muscle function. METHODS: Thirty young (20-35 yr) and 50 older...

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PMID: 38934509
DOI: 10.1249/mss.0000000000003508

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