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Article

Transcription factors specifying dopamine phenotype are decreased in cocaine users.

Neuroreport - 1 Mar 2004

Bannon Michael J, Pruetz Barb, Barfield Elaine, Schmidt Carl J

Abstract excerpt

During development, survival of midbrain dopamine neurons and specification of their phenotype are dependent upon the intracellular expression of a number of transcription factors, including Engrailed 1, Pitx3, and Nurr1. The role of these transcription factors in the maintenance of the dopaminer...

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Share to Cocaine-Related Disorders
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Nuclear Receptor Subfamily 4, Group A, Member 2

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Identifiers

PMID: 15094491
DOI: 10.1097/00001756-200403010-00003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15094491-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Transcription factors specifying dopamine phenotype are decreased in cocaine users.PMID 15094491Read ↗

Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers.Semantic proximity Read ↗

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A Molecular Profile of Cocaine Abuse Includes the Differential Expression of Genes that Regulate Transcription, Chromatin, and Dopamine Cell PhenotypeSemantic proximity Read ↗

Genetic and epigenetic control of midbrain dopaminergic neuron development.Semantic proximity Read ↗

Differentially expressed gene networks, biomarkers, long noncoding RNAs, and shared responses with cocaine identified in the midbrains of human opioid abusersSemantic proximity Read ↗

The control of dopamine neuron development, function and survival: insights from transgenic mice and the relevance to human disease.Semantic proximity Read ↗

Specification of dopaminergic subsets involves interplay of En1 and Pitx3.Semantic proximity Read ↗

Nurr1 enhances transcription of the human dopamine transporter gene through a novel mechanismSemantic proximity Read ↗

Reelin marks cocaine-activated striatal ensembles, promotes neuronal excitability, and regulates cocaine rewardSemantic proximity Read ↗

Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype.Semantic proximity Read ↗

MiR-9, miR-153 and miR-124 are down-regulated by acute exposure to cocaine in a dopaminergic cell model and may contribute to cocaine dependence.Semantic proximity Read ↗

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