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Article

Identification of m6A residues at single-nucleotide resolution using eCLIP and an accessible custom analysis pipeline.

RNA (New York, N.Y.) - 1 Apr 2021

Roberts Justin T, Porman Allison M, Johnson Aaron M

Abstract excerpt

Methylation at the N6 position of adenosine (m6A) is one of the most abundant RNA modifications found in eukaryotes; however, accurate detection of specific m6A nucleotides within transcripts has been historically challenging due to m6A and unmodified adenosine having virtually indistinguishable chemical properties. While previous strategies such as methyl-RNA immunoprecipitation and sequencing (MeRIP-seq) have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33376190
DOI: 10.1261/rna.078543.120
PMCID: PMC7962486

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