Article
The importance of conserved amino acids in heme-based globin-coupled diguanylate cyclases.
PloS one - 1 Jan 2017
Wan Xuehua, Saito Jennifer A, Newhouse James S, Hou Shaobin, Alam Maqsudul
Abstract excerpt
Globin-coupled diguanylate cyclases contain globin, middle, and diguanylate cyclase domains that sense O2 to synthesize c-di-GMP and regulate bacterial motility, biofilm formation, and virulence. However, relatively few studies have extensively examined the roles of individual residues and domains of globin-coupled diguanylate cyclases, which can shed light on their signaling mechanisms and provide drug targets....
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