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Article

More than Enzymes That Make or Break Cyclic Di-GMP-Local Signaling in the Interactome of GGDEF/EAL Domain Proteins of Escherichia coli.

mBio - 10 Oct 2017

Sarenko Olga, Klauck Gisela, Wilke Franziska M, Pfiffer Vanessa, Richter Anja M, Herbst Susanne, Kaever Volkhard, Hengge Regine

Abstract excerpt

The bacterial second messenger bis-(3'-5')-cyclic diguanosine monophosphate (c-di-GMP) ubiquitously promotes bacterial biofilm formation. Intracellular pools of c-di-GMP seem to be dynamically negotiated by diguanylate cyclases (DGCs, with GGDEF domains) and specific phosphodiesterases (PDEs, with EAL or HD-GYP domains). Most bacterial species possess multiple DGCs and PDEs, often with surprisingly distinct and...

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Identifiers

PMID: 29018125
DOI: 10.1128/mBio.01639-17
PMCID: PMC5635695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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