Article
Identification of a diguanylate cyclase and its role in Porphyromonas gingivalis virulence.
Infection and immunity - 1 Jul 2014
Chaudhuri Swarnava, Pratap Siddharth, Paromov Victor, Li Zhijun, Mantri Chinmay K, Xie Hua
Abstract excerpt
Porphyromonas gingivalis is a Gram-negative obligate anaerobic bacterium and is considered a keystone pathogen in the initiation of periodontitis, one of the most widespread infectious diseases. Bacterial bis-(3'-5') cyclic GMP (cyclic di-GMP [c-di-GMP]) serves as a second messenger and is involved in modulating virulence factors in numerous bacteria. However, the role of this second messenger has not been...
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