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Article

The association of genetic variations in DNA repair pathways with severe toxicities in NSCLC patients undergoing platinum-based chemotherapy.

International journal of cancer - 1 Dec 2017

Zheng Yi, Deng Zheng, Yin Jiye, Wang Shiming, Lu Daru, Wen Xiaoke, Li Xiangping, Xiao Di, Hu Chengping, Chen Xiang, Zhang Wei, Zhou Honghao, Liu Zhaoqian

Abstract excerpt

Genetic variations in genes involved in repairing platinum-induced DNA lesions may contribute to the toxicity of platinum-based chemotherapy. The role of single-nucleotide polymorphisms (SNPs) within DNA repair pathways in the occurrence of severe toxicity is not yet understood. Current studies prefer to do original works rather than analyze previously published data. Our study aimed to replicate associations...

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Source

Identifiers

PMID: 28791697
DOI: 10.1002/ijc.30921

Genes

XPC
RRM1
FANCC
PMS2

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