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Article

Association of XPD polymorphisms with severe toxicity in non-small cell lung cancer patients in a Chinese population.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2009

Wu Wenting, Zhang Wei, Qiao Rong, Chen Dan, Wang Huibo, Wang Yi, Zhang Shuyu, Gao Ge, Gu Aiqin, Shen Jie, Qian Ji, Fan Weiwei, Jin Li, Han Baohui, Lu Daru

Abstract excerpt

PURPOSE: Platinum agents cause DNA cross-linking and adducts. Xeroderma pigmentosum group D (XPD) plays a key role in the nucleotide excision repair pathway of DNA repair. Genetic polymorphisms of XPD may affect the capacity to remove the deleterious DNA lesions in normal tissues and lead to greater treatment-related toxicity. This study aimed to investigate the association of three polymorphisms of XPD at codons...

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Identifiers

PMID: 19458053
DOI: 10.1158/1078-0432.CCR-08-2715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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