Article
Genome-wide association study of myelosuppression in non-small-cell lung cancer patients with platinum-based chemotherapy.
The pharmacogenomics journal - 1 Feb 2016
Cao S, Wang S, Ma H, Tang S, Sun C, Dai J, Wang C, Shu Y, Xu L, Yin R, Song X, Chen H, Han B, Li Q, Wu J, Bai C, Chen J, Jin G, Hu Z, Lu D, Shen H
Abstract excerpt
Platinum-induced myelosuppression severely impedes successful chemotherapy in non-small-cell lung cancer (NSCLC) patients. Hence, it is clinically important to identify the patients who are at high risk for severe toxicity to certain chemotherapy. We first carried out a genome-wide scan of 906 703 single-nucleotide polymorphisms (SNPs) to identify genetic variants associated with platinum-induced myelosuppression...
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