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Article

Association between DNA mismatch repair gene polymorphisms and platinum-based chemotherapy toxicity in non-small cell lung cancer patients.

Chinese journal of cancer - 16 Jan 2017

Liu Jun-Yan, Qian Chen-Yue, Gao Yuan-Feng, Chen Juan, Zhou Hong-Hao, Yin Ji-Ye

Abstract excerpt

BACKGROUND: Chemotherapy toxicity is a serious problem from which non-small cell lung cancer (NSCLC) patients suffer. The mismatch repair (MMR) system is associated with platinum-based chemotherapy toxicity in NSCLC patients. In this study, we aimed to investigate the relationship between genetic polymorphisms in the MMR pathway and platinum-based chemotherapy toxicity in NSCLC patients. METHODS: A total of 220...

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Identifiers

PMID: 28093084
DOI: 10.1186/s40880-016-0175-2
PMCID: PMC5238520

Genes

MSH5
MSH2
MSH3

Provenance

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