Article
The study of the relation of DNA repair pathway genes SNPs and the sensitivity to radiotherapy and chemotherapy of NSCLC.
Scientific reports - 1 Jun 2016
Wang Chunbo, Nie Huan, Li Yiqun, Liu Guiyou, Wang Xu, Xing Shijie, Zhang Liping, Chen Xin, Chen Yue, Li Yu
Abstract excerpt
To analyze the relation between SNPs in DNA repair pathway-related genes and sensitivity of tumor radio-chemotherapy, 26 SNPs in 20 DNA repair genes were genotyped on 176 patients of NSCLC undertaking radio-chemotherapy treatment. In squamous cell carcinoma (SCC), as the rs2228000, rs2228001 (XPC), rs2273953 (TP73), rs2279744 (MDM2), rs2299939 (PTEN) and , (DNA-PKcs) affected the sensitivity...