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Article

Silencing Intersectin 1 Slows Orthotopic Neuroblastoma Growth in Mice.

Journal of pediatric hematology/oncology - 1 Nov 2017

Harris Jamie, Herrero-Garcia Erika, Russo Angela, Kajdacsy-Balla Andre, O'Bryan John P, Chiu Bill

Abstract excerpt

Neuroblastoma accounts for 15% of all pediatric cancer deaths. Intersectin 1 (ITSN1), a scaffold protein involved in phosphoinositide 3-kinase (PI3K) signaling, regulates neuroblastoma cells independent of MYCN status. We hypothesize that by silencing ITSN1 in neuroblastoma cells, tumor growth will be decreased in an orthotopic mouse tumor model. SK-N-AS neuroblastoma cells transfected with empty vector (pSR),...

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Source

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Identifiers

PMID: 28787396
DOI: 10.1097/MPH.0000000000000931
PMCID: PMC5656511

Genes

ITSN1
MYCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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