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Article

Paracrine Signaling Through MYCN Enhances Tumor-Vascular Interactions in Neuroblastoma

4 Jan 2012

Abstract excerpt

Neuroblastoma, a tumor of peripheral neural crest origin, numbers among the most common childhood cancers. Both amplification of the proto-oncogene MYCN and increased neoangiogenesis mark high-risk disease. Because angiogenesis is regulated by phosphatidylinositol 3-kinase (PI3K), we tested a clinical PI3K inhibitor, NVP-BEZ235, in MYCN-dependent neuroblastoma. NVP-BEZ235 decreased angiogenesis and improved...

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PMID: 22218692
DOI: 10.1126/scitranslmed.3002977

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