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Article

Neuroblastoma patient-derived orthotopic xenografts reflect the microenvironmental hallmarks of aggressive patient tumours.

Cancer letters - 1 Jun 2016

Braekeveldt Noémie, Wigerup Caroline, Tadeo Irene, Beckman Siv, Sandén Caroline, Jönsson Jimmie, Erjefält Jonas S, Berbegall Ana P, Börjesson Anna, Backman Torbjörn, Øra Ingrid, Navarro Samuel, Noguera Rosa, Gisselsson David, Påhlman Sven, Bexell Daniel

Abstract excerpt

Treatment of high-risk childhood neuroblastoma is a clinical challenge which has been hampered by a lack of reliable neuroblastoma mouse models for preclinical drug testing. We have previously established invasive and metastasising patient-derived orthotopic xenografts (PDXs) from high-risk neuroblastomas that retained the genotypes and phenotypes of patient tumours. Given the important role of the tumour...

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Identifiers

PMID: 27000989
DOI: 10.1016/j.canlet.2016.02.046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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