Predicting outcomes of EGFR-targeted therapy in non-small cell lung cancer patients using pleural effusions samples and peptide nucleic acid probe assay.

doi:10.1515/cclm-2016-0809

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Predicting outcomes of EGFR-targeted therapy in non-small cell lung cancer patients using pleural effusions samples and peptide nucleic acid probe assay.

Clinical chemistry and laboratory medicine - 26 Oct 2017

Wang Mei-Chia, Wang Chih-Liang, Chen Tai-Long, Chang John Wen-Cheng, Lu Jang-Jih, Chang Pi-Yueh, Chiou Chiuan-Chian

Abstract excerpt

BACKGROUND: Mutation of epidermal growth factor receptor (EGFR) is a prediction marker of the response to tyrosine kinase inhibitor (TKI) drugs in non-small cell lung cancer (NSCLC) patients. As late stage lung cancer patients rarely undergo surgery, samples for EGFR mutation identification usually come from computed tomography (CT)-guided or endoscopic biopsies, which is invasive and costly. Pleural effusion may...

Topics

Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Carcinoma, Non-Small-Cell Lung
DNA Probes
ErbB Receptors
Female
Humans
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Mutation

Peptide Nucleic Acids

Pleural Effusion

Protein Kinase Inhibitors

Treatment Outcome

Source

Open in PubMed

Identifiers

PMID: 28787267
DOI: 10.1515/cclm-2016-0809

Genes

EGFR

Variants

Provenance

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