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Epidermal Growth Factor Receptor Mutation and Anaplastic Lymphoma Kinase Gene Fusion: Detection in Malignant Pleural Effusion by RNA or PNA Analysis.

PloS one - 1 Jan 2016

Chen Yi-Lin, Lee Chung-Ta, Lu Cheng-Chan, Yang Shu-Ching, Chen Wan-Li, Lee Yang-Cheng, Yang Chung-Hsien, Peng Shu-Ling, Su Wu-Chou, Chow Nan-Haw, Ho Chung-Liang

Abstract excerpt

Analyzing EGFR mutations and detecting ALK gene fusion are indispensable when planning to treat pulmonary adenocarcinoma. Malignant pleural effusion (MPE) is a devastating complication of lung cancer and sometimes the only source for mutation analysis. The percentage of tumor cells in the pleural effusion may be low; therefore, mutant enrichment is required for a successful analysis. The EGFR mutation status in...

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Anaplastic Lymphoma Kinase
ErbB Receptors
Gene Fusion
Molecular Diagnostic Techniques
Pleural Effusion, Malignant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor Protein-Tyrosine Kinases

Sensitivity and Specificity

Sequence Analysis, RNA

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Identifiers

PMID: 27352172
DOI: 10.1371/journal.pone.0158125
PMCID: PMC4924845

Genes

EGFR
ALK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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