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EGFR mutation status in tumour-derived DNA from pleural effusion fluid is a practical basis for predicting the response to gefitinib.

British journal of cancer - 20 Nov 2006

Kimura H, Fujiwara Y, Sone T, Kunitoh H, Tamura T, Kasahara K, Nishio K

Abstract excerpt

Epidermal growth factor receptor (EGFR) mutations are strong determinants of tumour response to EGFR tyrosine kinase inhibitors in non-small-cell lung cancer (NSCLC). Pleural effusion is a common complication of lung cancer. In this study, we assessed the feasibility of detection of EGFR mutations in samples of pleural effusion fluid. We obtained 43 samples, which was the cell-free supernatant of pleural fluid,...

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Adenocarcinoma
Carcinoma, Large Cell
Carcinoma, Squamous Cell
DNA, Neoplasm
Feasibility Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pleural Effusion, Malignant

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Identifiers

PMID: 17060940
DOI: 10.1038/sj.bjc.6603428
PMCID: PMC2360588

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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