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Article

Pulmonary CCR2+CD4+ T cells are immune regulatory and attenuate lung fibrosis development.

Thorax - 1 Nov 2017

Milger Katrin, Yu Yingyan, Brudy Eva, Irmler Martin, Skapenko Alla, Mayinger Michael, Lehmann Mareike, Beckers Johannes, Reichenberger Frank, Behr Jürgen, Eickelberg Oliver, Königshoff Melanie, Krauss-Etschmann Susanne

Abstract excerpt

BACKGROUND: Animal models have suggested that CCR2-dependent signalling contributes to the pathogenesis of pulmonary fibrosis, but global blockade of CCL2 failed to improve the clinical course of patients with lung fibrosis. However, as levels of CCR2+CD4+ T cells in paediatric lung fibrosis had previously been found to be increased, correlating with clinical symptoms, we hypothesised that distinct CCR2+ cell...

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Share to Bronchoalveolar Lavage Fluid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lung Diseases, Interstitial

Share to Predictive Value of Tests

Share to Receptors, CCR2

Share to Sensitivity and Specificity

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Share to T-Lymphocytes, Regulatory

Source

Identifiers

PMID: 28780502
DOI: 10.1136/thoraxjnl-2016-208423

Genes

CCR2
CCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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