Article
UBE2O remodels the proteome during terminal erythroid differentiation.
Science (New York, N.Y.) - 4 Aug 2017
Nguyen Anthony T, Prado Miguel A, Schmidt Paul J, Sendamarai Anoop K, Wilson-Grady Joshua T, Min Mingwei, Campagna Dean R, Tian Geng, Shi Yuan, Dederer Verena, Kawan Mona, Kuehnle Nathalie, Paulo Joao A, Yao Yu, Weiss Mitchell J, Justice Monica J, Gygi Steven P, Fleming Mark D, Finley Daniel
Abstract excerpt
During terminal differentiation, the global protein complement is remodeled, as epitomized by erythrocytes, whose cytosol is ~98% globin. The erythroid proteome undergoes a rapid transition at the reticulocyte stage; however, the mechanisms driving programmed elimination of preexisting cytosolic proteins are unclear. We found that a mutation in the murine Ube2o gene, which encodes a ubiquitin-conjugating enzyme...
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