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Human hematopoietic stem cell vulnerability to ferroptosis

1 Feb 2023

Abstract excerpt

Hematopoietic stem cells (HSCs) have a number of unique physiologic adaptations that enable lifelong maintenance of blood cell production, including a highly regulated rate of protein synthesis. Yet, the precise vulnerabilities that arise from such adaptations have not been fully characterized. Here, inspired by a bone marrow failure disorder due to the loss of the histone deubiquitinase MYSM1, characterized by...

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PMID: 36803603
DOI: 10.1016/j.cell.2023.01.020

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