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Article

D-Galactose induces the senescence and senescence-related secretory phenotype switch of nucleus pulposus cells.

Experimental gerontology - 1 Feb 2026

Zhang ShuWen, Du Jing, Aikeremu Dilimulati, Ma ZhanBin, Wang Hao

Abstract excerpt

Senescence of nucleus pulposus cells (NPCs) in degenerative intervertebral discs is related to the development and progression of intervertebral disc degeneration (IVDD). The aim of this study was to establish a reliable and robust cell senescent model using D-galactose (D-Gal) to induce oxidative stress in NPCs. NPCs were isolated from Sprague Dawley rats and incubated with increasing concentrations of D-Gal....

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PMID: 41519276
DOI: 10.1016/j.exger.2026.113025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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