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Article

p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle.

eLife - 3 Mar 2020

Che Hui, Li Jie, Li You, Ma Cheng, Liu Huan, Qin Jingyi, Dong Jianghui, Zhang Zhen, Xian Cory J, Miao Dengshun, Wang Liping, Ren Yongxin

Abstract excerpt

The cell cycle regulator p16 is known as a biomarker and an effector of aging. However, its function in intervertebral disc degeneration (IVDD) is unclear. In this study, p16 expression levels were found to be positively correlated with the severity of human IVDD. In a mouse tail suspension (TS)-induced IVDD model, lumbar intervertebral disc height index and matrix protein expression levels were reduced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 32125276
DOI: 10.7554/eLife.52570
PMCID: PMC7065909

Genes

E2F1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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