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Article

Pharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias.

PloS one - 1 Jan 2017

Janovick Jo Ann, Spicer Timothy P, Bannister Thomas D, Scampavia Louis, Conn P Michael

Abstract excerpt

Pharmacoperones are small molecules that diffuse into cells and rescue misfolded, mistrafficked protein mutants, restoring their function. These substances act with high target specificity, serving as templates to fold (or refold) receptors, enzymes, ion channels or other proteins and enable them to pass the scrutiny of the cellular quality control system ("rescue"). In the present study we demonstrate that a...

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Identifiers

PMID: 28767678
DOI: 10.1371/journal.pone.0181830
PMCID: PMC5540481

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