Misfolding of vasopressin receptors: biased agonist pharmacochaperones as potential therapeutics.

doi:10.1016/bs.apcsb.2019.07.002

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Article

Misfolding of vasopressin receptors: biased agonist pharmacochaperones as potential therapeutics.

Advances in protein chemistry and structural biology - 1 Jan 2019

Mendre Christiane, Mouillac Bernard

Abstract excerpt

Biased agonists and pharmacological chaperones have demonstrated their potential to harness G protein-coupled receptor signaling and trafficking, and have collectively opened new possibilities in G protein-coupled receptor drug discovery. Combining pharmacological chaperoning and biased agonism properties into a unique given molecule would be of high therapeutic interest in many human diseases resulting from G...

Topics

Diabetes Insipidus, Nephrogenic
Drug Discovery
High-Throughput Screening Assays
Humans
Ligands
Mutation
Protein Folding
Receptors, Vasopressin

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Identifiers

PMID: 31928727
DOI: 10.1016/bs.apcsb.2019.07.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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