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Article

Molecular mechanism of action of pharmacoperone rescue of misrouted GPCR mutants: the GnRH receptor.

Molecular endocrinology (Baltimore, Md.) - 1 Feb 2009

Janovick Jo Ann, Patny Akshay, Mosley Ralph, Goulet Mark T, Altman Michael D, Rush Thomas S, Cornea Anda, Conn P Michael

Abstract excerpt

The human GnRH receptor (hGnRHR), a G protein-coupled receptor, is a useful model for studying pharmacological chaperones (pharmacoperones), drugs that rescue misfolded and misrouted protein mutants and restore them to function. This technique forms the basis of a therapeutic approach of rescuing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19095769
DOI: 10.1210/me.2008-0384
PMCID: PMC2646616

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-19095769-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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