Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rescue of vasopressin V2 receptor mutants by chemical chaperones: specificity and mechanism.

Molecular biology of the cell - 1 Jan 2006

Robben J H, Sze M, Knoers N V A M, Deen P M T

Abstract excerpt

Because missense mutations in genetic diseases of membrane proteins often result in endoplasmic reticulum (ER) retention of functional proteins, drug-induced rescue of their cell surface expression and understanding the underlying mechanism are of clinical value. To study this, we tested chemical chaperones and sarco(endo)plasmic reticulum Ca2+ ATPase pump inhibitors on Madin-Darby canine kidney cells expressing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Membrane Permeability
Share to Curcumin
Share to Cytosol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ionomycin

Share to Molecular Chaperones

Share to Receptors, Vasopressin

Share to Thapsigargin

Share to Valine

Source

Open in PubMed Open full text

Identifiers

PMID: 16267275
DOI: 10.1091/mbc.e05-06-0579
PMCID: PMC1345675

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rescue of vasopressin V2 receptor mutants by chemical chaperones: specificity and mechanism.PMID 16267275Read ↗

Vasopressin receptors and pharmacological chaperones: from functional rescue to promising therapeutic strategies.Semantic proximity Read ↗

Molecular genetic study of congenital nephrogenic diabetes insipidus and rescue of mutant vasopressin V2 receptor by chemical chaperones.Semantic proximity Read ↗

Pharmacological Chaperones as Potential Therapeutic Strategies for Misfolded Mutant Vasopressin Receptors.Semantic proximity Read ↗

Pharmacological chaperones in nephrogenic diabetes insipidus: possibilities for clinical application.Semantic proximity Read ↗

Functional rescue of vasopressin V2 receptor mutants in MDCK cells by pharmacochaperones: relevance to therapy of nephrogenic diabetes insipidus.Semantic proximity Read ↗

Analysis of the V2 Vasopressin Receptor (V2R) Mutations Causing Partial Nephrogenic Diabetes Insipidus Highlights a Sustainable Signaling by a Non-peptide V2R Agonist.Semantic proximity Read ↗

Evaluation of pharmacochaperone-mediated rescue of mutant V2 receptor proteins.Semantic proximity Read ↗

Functional rescue of the constitutively internalized V2 vasopressin receptor mutant R137H by the pharmacological chaperone action of SR49059.Semantic proximity Read ↗

Characterization of vasopressin V2 receptor mutants in nephrogenic diabetes insipidus in a polarized cell model.Semantic proximity Read ↗

Compounds that correct F508del-CFTR trafficking can also correct other protein trafficking diseases: an in vitro study using cell linesSemantic proximity Read ↗

G protein-coupled receptor trafficking in health and disease: lessons learned to prepare for therapeutic mutant rescue in vivo.Semantic proximity Read ↗

Misfolding of vasopressin receptors: biased agonist pharmacochaperones as potential therapeutics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.