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Article

Identification of Potential Pharmacoperones Capable of Rescuing the Functionality of Misfolded Vasopressin 2 Receptor Involved in Nephrogenic Diabetes Insipidus.

Journal of biomolecular screening - 1 Sept 2016

Smith Emery, Janovick Jo Ann, Bannister Thomas D, Shumate Justin, Scampavia Louis, Conn P Michael, Spicer Timothy P

Abstract excerpt

Pharmacoperones correct the folding of otherwise misfolded protein mutants, restoring function (i.e., providing "rescue") by correcting their trafficking. Currently, most pharmacoperones possess intrinsic antagonist activity because they were identified using methods initially aimed at discovering such functions. Here, we describe an ultra-high-throughput homogeneous cell-based assay with a cAMP detection system,...

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Share to Diabetes Insipidus, Nephrogenic
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Screening Assays

Share to Protein Folding

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Share to Receptors, Vasopressin

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Source

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Identifiers

PMID: 27280550
DOI: 10.1177/1087057116653925
PMCID: PMC5594746

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Identification of Potential Pharmacoperones Capable of Rescuing the Functionality of Misfolded Vasopressin 2 Receptor Involved in Nephrogenic Diabetes Insipidus.PMID 27280550Read ↗

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